ELECTRICAL BURSTING AND INTRACELLULAR CA-2+ OSCILLATIONS IN EXCITABLE CELL MODELS

被引:35
作者
CHAY, TR
机构
[1] Department of Biological Sciences, University of Pittsburgh, Pittsburgh, 15260, PA
关键词
D O I
10.1007/BF00202449
中图分类号
TP3 [计算技术、计算机技术];
学科分类号
0812 ;
摘要
In bursting excitable cells such as pancreatic β-cells and molluscan Aplysia neuron cells, intracellular Ca2+ ion plays a central role in various cellular functions. To understand the role of [Ca2+]i (the intracellular Ca2+ concentration) in electrical bursting, we formulate a mathematical model which contains a few functionally important ionic currents in the excitable cells. In this model, inactivation of Ca2+ current takes place by a mixture of voltage and intracellular Ca2+ ions. The model predicts that, although the electrical bursting patterns look the same, the shapes of [Ca2+]i oscillations could be very different depending on how fast [Ca2+]i changes in the cytosolic free space (i.e., how strong the cellular Ca2+ buffering capacity is). If [Ca2+]i changes fast, [Ca2+]i oscillates in bursts in parallel to electrical bursting such that it reaches a maximum at the onset of bursting and a minimum just after the termination of the plateau phase. If the change is slow, then [Ca2+]i oscillates out-of-phase with electrical bursting such that it peaks at a maximum near the termination of the plateau and a minimum just before the onset of the active phase. During the active phase [Ca2+]i gradually increases without spikes. In the intermediate ranges, [Ca2+]i oscillates in such a manner that the peak of [Ca2+]i oscillation lags behind the electrical activity. The model also predicts the existence of multi-peaked oscillations and chaos in certain ranges of the gating variables and the intracellular Ca2+ buffer concentration. © 1990 Springer-Verlag.
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页码:15 / 23
页数:9
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