PIMOZIDE ENHANCES THE AVERSIVENESS OF QUININE SOLUTION

被引：18

作者：

PARKER, LA ^{[1
]}

LOPEZ, N ^{[1
]}

机构：

[1] SAM HOUSTON STATE UNIV, HUNTSVILLE, TX 77340 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 03期

关键词：

Amphetamine; Conditioned taste aversion; Dopamine; Lithium; Neuroleptics; Palatability; Pimozide; Psychopharmacology; Quinine; Sucrose; Taste; Taste reactivity;

D O I：

10.1016/0091-3057(90)90271-I

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The taste reactivity test was employed to assess the effect of pimozide pretreatment on rats' hedonic responsiveness to palatable and unpalatable tastants. Pimozide selectively enhanced the aversiveness of unconditionally unpalatable quinine solution (Experiment 1) and produced the greatest enhancement of aversion at the highest concentration of quinine (0.1%) solution tested (Experiment 3). Pimozide also enhanced the aversiveness of a conditionally unpalatable lithium-paired solution, but only when the dose of pimozide was relatively high and the strength of the baseline aversion was relatively low (Experiment 2). These results are discussed in light of the anhedonia and the sensorimotor deficit hypotheses of neuroleptic effects on reinforced responding. © 1990.

引用

页码：653 / 659

页数：7

共 24 条

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