ANTI-LEUKEMIC ACTIVITY OF SUBSTITUTED UREIDOTHIAZOLES, UREIDOTHIADIAZOLES, AND RELATED COMPOUNDS

被引：23

作者：

ZEECHENG, RKY ^{[1
]}

CHENG, CC ^{[1
]}

机构：

[1] MIDWEST RES INST,KANSAS CITY,MO 64110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 01期

关键词：

D O I：

10.1021/jm00187a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-([(2-thiazolylamino)carbonyl]. amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure activity relationship study revealed that, among other considerations, active compounds of this series contain either an “isothioureido” [>N C(S) ̿ N] or an “isothiosemicarbazono” [>N C(S)̿N N̿] structural unit. © 1979, American Chemical Society. All rights reserved.

引用

页码：28 / 32

页数：5

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