3 RECEPTOR-LINKED PROTEIN-TYROSINE PHOSPHATASES ARE SELECTIVELY EXPRESSED ON CENTRAL-NERVOUS-SYSTEM AXONS IN THE DROSOPHILA EMBRYO

被引:197
作者
TIAN, SS
TSOULFAS, P
ZINN, K
机构
[1] Division of Biology 216-76 California Institute of Technology Pasadena
关键词
D O I
10.1016/0092-8674(91)90063-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We describe the isolation of seven different protein-tyrosine phosphatase (PTPase) cDNAs from Drosophila embryos, three of which are primarily expressed in the central nervous system (CNS). The CNS-specific PTPases include the previously sequenced DLAR, as well as two novel PTPases (denoted DPTP10D and DPTP99A), which have extracellular domains consisting of multiple fibronectin type III repeats. Each of the Drosophila sequences is most closely related to a different human PTPase. The three PTPase mRNAs are expressed in different patterns of cells in the ventral nerve cord, and all three proteins are restricted to axons. DLAR and DPTP99A are apparently expressed on most or all axons, while DPTP10D is primarily localized to the anterior commissure and its junctions with the longitudinal tracts.
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页码:675 / 685
页数:11
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