HISTAMINE-RECEPTORS IN THE HEART AND CORONARY VESSELS OF RABBITS

被引：21

作者：

CORUZZI, G ^{[1
]}

BONGRANI, S ^{[1
]}

BERTACCINI, G ^{[1
]}

机构：

[1] UNIV PARMA,CHAIR CARDIOVASC DIS,I-43100 PARMA,ITALY

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1979年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0031-6989(79)80024-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Histamine and some H1- and H2 receptor agonists and antagonists, were investigated for their effect on contractile force, heart rate and coronary perfusion pressure of the isolated perfused rabbit heart. Results obtained suggested that the inotropic and chronotropic effects were connected with excitation of H2 receptors. The response of coronary vessels was connected with a predominant stimulation of H1 receptors (which caused vasoconstriction) and a less evident stimulation of H2 receptors (which caused vasodilation). Changes in coronary perfusion pressure were not correlated with myocardial metabolic changes induced by the different compounds. © 1979 The Italian Pharmacological Society.

引用

页码：517 / 528

页数：12

共 13 条

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