CANCER RISK IN 2ND-DEGREE RELATIVES OF CHILDREN WITH SOFT-TISSUE SARCOMA

被引:5
作者
HARTLEY, AL
BIRCH, JM
TEARE, MD
BLAIR, V
KELSEY, AM
机构
[1] Cancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital and Holt Radium Institute, Manchester
关键词
D O I
10.1038/bjc.1991.209
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The risk of cancer in the second degree relatives of a population-based series of children with soft tissue sarcoma was studied in relation to (i) various characteristics in these relatives, (ii) certain clinical features in the index children previously identified as risk factors for cancer in their first degree relatives. Overall there was a non-significant deficit of cancers in the second degree relatives (RR = 0.88) and cancer risk was unrelated to type or site of cancer, type of relative, or to risk factors in the index case. The findings indicate that although the families investigated may include a proportion with the Li-Fraumeni cancer family syndrome, the increased cancer risk already reported in the first degree relatives does not extend to second degree relatives in general.
引用
收藏
页码:959 / 962
页数:4
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