A MICROSATELLITE-BASED MULTIPOINT INDEX MAP OF HUMAN-CHROMOSOME-22

被引：27

作者：

BUETOW, KH

DUGGAN, D

YANG, BS

LUDWIGSEN, S

PUCK, J

PORTER, J

BUDARF, M

SPIELMAN, R

EMANUEL, BS

机构：

[1] CHILDRENS HOSP PHILADELPHIA,DIV HUMAN GENET,PHILADELPHIA,PA 19104

[2] UNIV PENN,DEPT HUMAN GENET,PHILADELPHIA,PA 19104

来源：

GENOMICS | 1993年 / 18卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1473

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Utilizing the CEPH (Centre d’Etude du Polymorphisme Humain) reference panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, we have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map. © 1993 Academic Press. All rights reserved.

引用

页码：329 / 339

页数：11

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