PROGNOSTIC-SIGNIFICANCE OF LAMININ PRODUCTION IN RELATION WITH ITS RECEPTOR EXPRESSION IN HUMAN BREAST CARCINOMAS

被引：59

作者：

PELLEGRINI, R

MARTIGNONE, S

TAGLIABUE, E

BELOTTI, D

BUFALINO, R

CASCINELLI, N

MENARD, S

COLNAGHI, MI

机构：

[1] IST NAZL TUMORI,DIV EXPTL ONCOL E,I-20133 MILAN,ITALY

[2] IST MARIO NEGRI,BERGAMO,ITALY

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1995年 / 35卷 / 02期

关键词：

BREAST CANCER; LAMININ; LAMININ RECEPTOR; METASTASIS; PROGNOSIS;

D O I：

10.1007/BF00668209

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Laminin is a basement membrane glycoprotein whose expression has been widely related to cancer progression. Laminin production by primary breast carcinomas was investigated using immunohistochemistry on archival specimens from a retrospective series with long term follow-up. Laminin production was found to be independent of the clinical and pathological variables analyzed, whereas a statistically significant direct association with the expression of the laminin receptor and a negative association with the differentiation-related antigen Ca-MBr8 were observed. Survival analysis indicated that laminin positivity by itself has no prognostic significance. However, when analyzed together with the laminin receptor expression, laminin was associated with a good prognosis in receptor-negative tumors and with the worst prognosis in receptor-positive tumors.

引用

页码：195 / 199

页数：5

共 24 条

[1]

ALBRECHTSEN R, 1981, CANCER RES, V41, P5076

[2] LAMININ MOLECULAR DOMAINS WHICH ALTER METASTASIS IN A MURINE MODEL [J].