A METHOD FOR THE SYNTHESIS OF THE ENANTIOMERS OF PROPAFENONE

被引：9

作者：

ECKER, G

FLEISCHHACKER, W

NOE, CR

机构：

[1] Institut für Pharmazeutische Chemie, Universität Wien, Wien, A-1090

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 11期

关键词：

D O I：

10.1002/ardp.19943271104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The enantiomers of the antiarrhythmic drug propafenone were synthesized using a recoverable acetal protective group. The key-step in the synthesis was the protection of the cyanohydrin 7 with enantiomerically pure MBF-lactol, which allows not only easy separation of diastereomers using vacuum-flash-chromatography, but also reliable assignment of absolute configuration and determination of diastereomeric purity by means of hplc and nmr.

引用

页码：691 / 695

页数：5

共 10 条

[1]

BLASCHKE G, 1987, LIEBIGS ANN CHEM, P561

[2]

COREY EJ, 1979, TETRAHEDRON LETT, P399

[3]

FRANKE A, 1989, Patent No. 301449

[4] THE EFFECTS OF THE STEREOISOMERS OF PROPAFENONE AND DIPRAFENONE IN GUINEA-PIG HEART [J].