INTRATHECAL ALPHA-TRINOSITOL FACILITATES THE FLEXOR REFLEX BUT DOES NOT BLOCK THE DEPRESSIVE EFFECT OF NEUROPEPTIDE-Y

被引：3

作者：

XU, XJ

WIESENFELDHALLIN, Z

机构：

[1] Department of Medical Laboratory Sciences and Technology, Section of Clinical Neurophysiology, Huddinge University Hospital

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 272卷 / 2-3期

关键词：

FLEXOR REFLEX; INOSITOL TRISPHOSPHATE; MOTONEURON; NEUROPEPTIDE Y; NOCICEPTION; SPINAL CORD;

D O I：

10.1016/0014-2999(94)00646-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have studied the effects of alpha-trinositol (D-myo-inositol-1,2,6-trisphosphate, PP56), a putative antagonist of neuropeptide tide Y receptors, on the nociceptive flexor reflex in decerebrate, spinalized rats after intrathecal and intravenous administration. Intrathecal alpha-trinositol caused strong and prolonged facilitation of the flexor reflex, which was usually associated with an increase in spontaneous motoneuron activity. The reflex depressive effect of intrathecal neuropeptide Y was neither blocked nor reversed by alpha-trinositol. Intravenous alpha-trinositol at low doses had no effect on the flexor reflex and at high dose, reflex facilitation was sometimes observed. It is concluded that alpha-trinositol acts as a spinal excitant and is not an antagonist of the neuropeptide Y receptor in the rat spinal cord.

引用

页码：219 / 222

页数：4

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