PHENYLALKANOL ADSORBATES ON SILICA AS TYPES OF IMMOBILIZED DRUGS .1. CHEMIADSORPTION ON ACTIVATED SILICA SURFACES

被引：9

作者：

ECKERTLILL, C ^{[1
]}

LILL, NA ^{[1
]}

RUPPRECHT, H ^{[1
]}

机构：

[1] UNIV REGENSBURG,INST PHARM,DEPT PHARMACEUT TECHNOL,UNIV STR 31,D-8400 REGENSBURG,FED REP GER

来源：

COLLOID AND POLYMER SCIENCE | 1987年 / 265卷 / 11期

关键词：

ADSORBENTS - Activation - ADSORPTION - Chemical Reactions - ALCOHOLS - Adsorption - SILICA - Chlorination;

D O I：

10.1007/BF01412404

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The chemiadsorption of phenylalkanols onto a porous silica support was studied. The silica support was activated prior to the alcohol adsorption by annealing or by the introduction of Si-Cl groups. Different reaction conditions were applied, namely time, temperature, solvent and drug-support ratio. The yield of chemiadsorption was dependent on both the reaction conditions and the structure of the alcohols. Long alkyl chains, especially those with an alcohol OH-group positioned in the vicinity of bulky substituents, reduce the yield considerably. Using chlorinated silica, a reasonable yield of chemiadsorption can be obtained even at relatively low reaction temperatures.

引用

页码：1001 / 1008

页数：8

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