INFLUENCE OF TESTICULAR MICROANATOMY ON THE POTENTIAL GENETIC DOSE FROM INTERNALLY DEPOSITED PU-239 CITRATE IN CHINESE-HAMSTER, MOUSE, AND MAN

被引：18

作者：

BROOKS, AL

DIEL, JH

MCCLELLAN, RO

机构：

来源：

RADIATION RESEARCH | 1979年 / 77卷 / 02期

关键词：

D O I：

10.2307/3575141

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The localization, retention, and microdistribution of 239Pu citrate in the testes of the Chinese hamster were determined. Testicular morphometric measurements were made in adult mice and Chinese hamsters as well as in aged, adult, and immature humans. Calculations based on these morphometric measurements and a nonuniform microdistribution of plutonium indicated that the radiation dose to spermatogonia of man was less than that predicted from a uniform distribution of activity. This contrasts with the enhanced dose to the spermatogonia in mouse and Chinese hamsters produced by the unique microanatomy and nonuniform deposition of plutonium in the testes of rodents. Levels of 239Pu which induced marked life shortening and increased cancer incidence caused no significant increase in the frequency of mitotic chromosome aberrations in spermatogonia.

引用

页码：292 / 302

页数：11

共 13 条

[1] COMPARISON OF MONOMERIC AND POLYMERIC PLUTONIUM IN DOG AND MOUSE
BAXTER, DW
ROSENTHAL, MW
RUSSELL, JJ
MORETTI, E
CHLADEK, D
LINDENBAUM, A
[J]. RADIATION RESEARCH, 1973, 54 (03) : 556 - 565
[2] CYTOGENETIC EFFECTS OF PLUTONIUM-239 IN MALE MICE
BEECHEY, CV
GREEN, D
HUMPHREYS, ER
SEARLE, AG
[J]. NATURE, 1975, 256 (5518) : 577 - 578
[3] BENJAMIN SA, 1976, BIOL ENV EFFECTS LOW, V2, P143
[4] COMPARISON OF RADIATION-INDUCED CHROMATID ABERRATIONS IN TESTES AND BONE MARROW OF CHIMESE HAMSTER
BROOKS, AL
LENGEMANN, FW
[J]. RADIATION RESEARCH, 1967, 32 (03) : 587 - +
[5] CHROMOSOME DAMAGE IN LIVER-CELLS FROM LOW-DOSE RATE ALPHA, BETA, AND GAMMA-IRRADIATION - DERIVATION OF RBE
BROOKS, AL
[J]. SCIENCE, 1975, 190 (4219) : 1090 - 1092
[6] COMPARISON OF LETHALITY AND CHROMOSOMAL DAMAGE INDUCED BY X-RAYS IN SYNCHRONIZED CHINESE HAMSTER CELLS IN-VITRO
DEWEY, WC
FURMAN, SC
MILLER, HH
[J]. RADIATION RESEARCH, 1970, 43 (03) : 561 - +
[7] LOCALIZATION OF PLUTONIUM IN MOUSE TESTES
GREEN, D
HOWELLS, GR
HUMPHREYS, ER
VENNART, J
[J]. NATURE, 1975, 255 (5503) : 77 - 77
[8] ALPHA ABSORPTION-MEASUREMENTS APPLIED TO LUNG DOSE FROM PLUTONIUM-239
HARLEY, NH
PASTERNACK, BS
[J]. HEALTH PHYSICS, 1975, 28 (01): : 61 - 67
[9] LUNING KG, 1976, BIOL ENV EFFECTS LOW, V1, P39
[10] PLUTONIUM AND OTHER ACTINIDE ELEMENTS IN GONADAL TISSUE OF MAN AND ANIMALS
RICHMOND, CR
THOMAS, RL
[J]. HEALTH PHYSICS, 1975, 29 (02): : 241 - 250

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