HIGH DIASTEREOSELECTION IN THE ALDOL REACTION OF THE BISTRIMETHYLSILYL ENOL ETHER OF METHYL ACETOACETATE WITH 2-BENZYLOXYHEXANAL - SYNTHESIS OF (-)-PESTALOTIN

被引：28

作者：

HAGIWARA, H

KIMURA, K

UDA, H

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 06期

关键词：

D O I：

10.1039/p19920000693

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldol condensation of the bistrimethylsilyl enol ether of methyl acetoacetate, compound 2, with 2-benzyloxyhexanal 3c affords highly selectively (99:1) the syn-aldol adduct 4c in the presence of titanium tetrachloride. The stereocontrolled synthesis of (-)-pestalotin 7 has been achieved.

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页码：693 / 700

页数：8

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