CYCLIC-AMP ANALOGS INCREASE EXCITABILITY AND ENHANCE EPILEPTIFORM ACTIVITY IN RAT NEOCORTEX INVITRO

被引：24

作者：

BOULTON, CL ^{[1
]}

MCCROHAN, CR ^{[1
]}

OSHAUGHNESSY, CT ^{[1
]}

机构：

[1] UNIV MANCHESTER, DEPT PHYSIOL SCI, MANCHESTER M13 9PT, LANCS, ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 236卷 / 01期

基金：

英国惠康基金;

关键词：

EPILEPTIFORM ACTIVITY; CAMP; FORSKOLIN; NEOCORTEX;

D O I：

10.1016/0014-2999(93)90235-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effects of the cyclic AMP agonists 8-(4-chlorophenylthio)-adenosine 3': 5' cyclic monophosphate (CPT-cAMP), dibutyryl cyclic AMP (dbcAMP) and forskolin were studied on extracellular field potentials in rat neocortex slices in vitro. CPT-cAMP and forskolin produced a prolonged enhancement of epileptiform activity resulting from removal of Mg2+ from the bathing medium. DbcAMP had no apparent effect except at high concentrations (1 mM), when it reduced bursting activity. Field potentials observed following electrical stimulation of the corpus callosum in the presence of Mg2+ were enhanced by CPT-cAMP and dbcAMP; however forskolin was without effect. Intracellular recording techniques demonstrated a transient excitatory influence of dbcAMP. The results indicate a role for cyclic AMP in seizure mechanisms.

引用

页码：131 / 136

页数：6

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