CHALLENGES IN THE THERAPY OF HIV-INFECTION

被引：18

作者：

YARCHOAN, R ^{[1
]}

MITSUYA, H ^{[1
]}

BRODER, S ^{[1
]}

机构：

[1] NCI,MED BRANCH,EXPTL RETROVIRAL SECT,BETHESDA,MD 20892

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 05期

关键词：

D O I：

10.1016/0165-6147(93)90208-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drugs that inhibit human immunodeficiency virus (HIV) replication have been shown to have clinical utility in patients with HIV infection. However, the immunological improvement induced by available anti-HIV therapies in patients with acquired immune deficiency syndrome (AIDS) is incomplete and transient. Explanations for this may include immunological barriers to complete reconstitution, low therapeutic indices of the available drugs, and the development of viral resistance. An understanding of these processes, as discussed here by Robert Yarchoan and colleagues, may provide important leads for the development of improved therapy for AIDS.

引用

页码：196 / 202

页数：7

共 60 条

[1] INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS IN EARLY INFECTED AND CHRONICALLY INFECTED-CELLS BY ANTISENSE OLIGODEOXYNUCLEOTIDES AND THEIR PHOSPHOROTHIOATE ANALOGS [J].

AGRAWAL, S ;

IKEUCHI, T ;

SUN, D ;

SARIN, PS ;

KONOPKA, A ;

MAIZEL, J ;

ZAMECNIK, PC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :7790-7794

[2] CELLULAR PROTEINS BOUND TO IMMUNODEFICIENCY VIRUSES - IMPLICATIONS FOR PATHOGENESIS AND VACCINES [J].

ARTHUR, LO ;

BESS, JW ;

SOWDER, RC ;

BENVENISTE, RE ;

MANN, DL ;

CHERMANN, JC ;

HENDERSON, LE .

SCIENCE, 1992, 258 (5090) :1935-1938

[3]

BIRX DL, 1990, BLOOD, V76, P2303

[4] USE OF EVOLUTIONARY LIMITATIONS OF HIV-1 MULTIDRUG RESISTANCE TO OPTIMIZE THERAPY [J].

CHOW, YK ;

HIRSCH, MS ;

MERRILL, DP ;

BECHTEL, LJ ;

ERON, JJ ;

KAPLAN, JC ;

DAQUILA, RT .

NATURE, 1993, 361 (6413) :650-654

[5] A FACTOR FROM CD8 CELLS OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS SUPPRESSES HLA SELF-RESTRICTED T-HELPER CELL RESPONSES [J].

CLERICI, M ;

ROILIDES, E ;

VIA, CS ;

PIZZO, PA ;

SHEARER, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8424-8428

[6] A T(H)1-]T(H)2 SWITCH IS A CRITICAL STEP IN THE ETIOLOGY OF HIV-INFECTION [J].

CLERICI, M ;

SHEARER, GM .

IMMUNOLOGY TODAY, 1993, 14 (03) :107-110

[7] THE SEPARATED ENANTIOMERS OF 2'-DEOXY-3'-THIACYTIDINE (BCH-189) BOTH INHIBIT HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION INVITRO [J].

COATES, JAV ;

CAMMACK, N ;

JENKINSON, HJ ;

MUTTON, IM ;

PEARSON, BA ;

STORER, R ;

CAMERON, JM ;

PENN, CR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (01) :202-205

[8] HIGH-CONCENTRATIONS OF RECOMBINANT SOLUBLE CD4 ARE REQUIRED TO NEUTRALIZE PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES [J].

DAAR, ES ;

LI, XL ;

MOUDGIL, T ;

HO, DD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6574-6578

[9] POTENT AND SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-1 AND HIV-2 REPLICATION BY A CLASS OF BICYCLAMS INTERACTING WITH A VIRAL UNCOATING EVENT [J].

DECLERCO, E ;

YAMAMOTO, N ;

PAUWELS, R ;

BABA, M ;

SCHOLS, D ;

NAKASHIMA, H ;

BALZARINI, J ;

DEBYSER, Z ;

MURRER, BA ;

SCHWARTZ, D ;

THORNTON, D ;

BRIDGER, G ;

FRICKER, S ;

HENSON, G ;

ABRAMS, M ;

PICKER, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5286-5290

[10] DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE [J].

ERICKSON, J ;

NEIDHART, DJ ;

VANDRIE, J ;

KEMPF, DJ ;

WANG, XC ;

NORBECK, DW ;

PLATTNER, JJ ;

RITTENHOUSE, JW ;

TURON, M ;

WIDEBURG, N ;

KOHLBRENNER, WE ;

SIMMER, R ;

HELFRICH, R ;

PAUL, DA ;

KNIGGE, M .

SCIENCE, 1990, 249 (4968) :527-533

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