SYNTHESIS OF 3-NITROBENZO[A]PYRENE BAY-REGION TRANS-7,8-DIOL ANTI-9,10-EPOXIDE AND THE CORRESPONDING N(2)-DEOXYGUANOSINE ADDUCT

被引：10

作者：

FU, PP ^{[1
]}

WU, YS ^{[1
]}

VONTUNGELN, LS ^{[1
]}

LAI, JS ^{[1
]}

CHIARELLI, MP ^{[1
]}

EVANS, FE ^{[1
]}

机构：

[1] PROVIDENCE UNIV, INST APPL CHEM, TAICHUNG, TAIWAN

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1993年 / 6卷 / 05期

关键词：

D O I：

10.1021/tx00035a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Nitrobenzo[a]pyrene (3-nitro-BaP) is a potent mutagenic environmental contaminant, and its biological activities have been intensively studied. It is significant to prepare its reactive metabolites and the corresponding modified DNA adducts for biological studies. The synthesis of its oxidized proximate metabolite trans-7,8-dihydroxy-7,8-dihydro-3-nitrobenzo[a]pyrene (3-nitro-BaP-trans-7,8-dihydrodiol, 1), its oxidized ultimate metabolite trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydro-3-nitrobenzo[a]pyrene (3-nitro-BaP-DE, 2), and the corresponding DNA adduct 10-(deoxyguanosin-N2-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-3-nitrobenzo[a]pyrene is described.

引用

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页码：603 / 608

页数：6

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