GENOMIC CHARACTERIZATION OF HEPATITIS-C VIRUS ISOLATES FROM ARGENTINA

被引：23

作者：

OUBINA, JR ^{[1
]}

QUARLERI, JF ^{[1
]}

RUDZINSKI, M ^{[1
]}

PARKS, C ^{[1
]}

BADIA, I ^{[1
]}

CAPPA, SMG ^{[1
]}

机构：

[1] RICARDO GUTIERREZ CHILDRENS HOSP,HEPATOL UNIT 4,BUENOS AIRES,DF,ARGENTINA

来源：

JOURNAL OF MEDICAL VIROLOGY | 1995年 / 47卷 / 01期

关键词：

HEPATITIS C VIRUS; VIRAL GENOMES; HCV GENOTYPES;

D O I：

10.1002/jmv.1890470118

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Thirty-three Argentinian patients infected with hepatitis C virus (HCV) were studied for viral genotyping. The patients included 10 hemophiliac and 4 polytransfused children and 19 adults: 3 polytransfused, 7 dialyzed and 9 sporadic cases. Core-based genotyping permitted the classification of 31 samples. Genotypes II, I and V were the most frequent: 21 (63.6%), 16 (48.4%) and 10 (30.3%) of the 33 patients, respectively. Only one polytransfused patient carried genotype IV. Genotype II was detected in 7 out of 9 sporadic cases. Thirteen patients (39.3%) were coinfected with two genotypes, and 2 others were coinfected with three genotypes. The remaining 2 samples which could not be typed were characterized following the restriction fragment length polymorphism (RFLP) method, and were classified as type 1. One of these had two consecutive transitional mutations in the 5' untranslated region (5' UTR). (C) 1995 Wiley-Liss, Inc.

引用

页码：97 / 104

页数：8

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