CHEMISTRY AND BIOLOGY OF THE 2-BETA-ALKYL-3-BETA-PHENYL ANALOGS OF COCAINE - SUBNANOMOLAR AFFINITY LIGANDS THAT SUGGEST A NEW PHARMACOPHORE MODEL AT THE C-2 POSITION

被引:79
作者
KOZIKOWSKI, AP
SAIAH, MKE
JOHNSON, KM
BERGMANN, JS
机构
[1] MAYO FDN MED EDUC & RES,NEUROCHEM RES,JACKSONVILLE,FL
[2] UNIV TEXAS,MED BRANCH,DEPT PHARMACOL & TOXICOL,GALVESTON,TX 77555
关键词
D O I
10.1021/jm00016a012
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of 2 beta-alkyl-3 beta-phenyltropanes (i.e., the 2 beta-alkyl analogues of the WIN series) were prepared as analogues of cocaine and tested for their ability to displace [H-3]mazindol binding and to inhibit high-affinity dopamine uptake into striatal nerve endings (synaptosomes). These 2 beta-alkyl analogues were readily prepared in optically pure form starting from cocaine by proceeding through the 2 beta-phenyl-bearing aldehyde 6 as a key intermediate. Wittig reaction of 6 with the appropriate phosphorane and hydrogenation delivered the final products. Ah new compounds with the exception of 8e were found to exhibit nanomolar or subnanomolar affinity for the cocaine binding site in the rat striatum. These results are in apparent opposition to the binding model previously proposed which suggests a hydrogen bond donor-acceptor interaction to be present in the vicinity of the C-2 substituent. Taken together with our previous reports and recent findings from other laboratories, we suggest a new pharmacophore model in which 2 beta-substituents lacking H-bond accepters enhance affinity to the binding site through hydrophobic interactions. The new SAR data contained herein may be relevant to the design of possible cocaine antagonists.
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收藏
页码:3086 / 3093
页数:8
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