ENHANCEMENT OF CYTOSOLIC AND MICROSOMAL GLUTATHIONE-S-TRANSFERASE ACTIVITIES IN LIVER AND SMALL-INTESTINE FROM FEMALE RATS DURING LACTATION

被引：5

作者：

LUQUITA, MG ^{[1
]}

CATANIA, VA ^{[1
]}

POZZI, EJS ^{[1
]}

MOTTINO, AD ^{[1
]}

机构：

[1] UNIV NACL ROSARIO,FAC BIOCHEM & PHARMACEUT SCI,CONICET,INST EXPTL PHYSIOL,RA-2000 ROSARIO,ARGENTINA

来源：

PHARMACOLOGY & TOXICOLOGY | 1995年 / 76卷 / 01期

关键词：

D O I：

10.1111/j.1600-0773.1995.tb00106.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of lactation on hepatic and intestinal glutathione S-transferase activities in mother rats was studied. Cytosolic and microsomal activities were assessed 7, 14 and 21 days after delivery, using 1-chloro-2,4-dinitrobenzene as substrate. Cytosolic and microsomal activities from liver and small intestine determined 7 days post partum did not differ from those of virgin female rats. The hepatic cytosolic activity was significantly increased with respect to that of virgin females 14 days after delivery and tended to revert to the control value on day 21 of lactation, whereas the intestinal activity was increased on day 14 and remained augmented even 21 days post partum. Although the respective microsomal activities showed percent increases higher than those of the cytosolic enzymes, they both exhibited a similar pattern of stimulation in response to lactation.

引用

页码：72 / 75

页数：4

共 33 条

[1] PURIFICATION OF MAJOR BASIC GLUTATHIONE TRANSFERASE ISOENZYMES FROM RAT-LIVER BY USE OF AFFINITY-CHROMATOGRAPHY AND FAST PROTEIN LIQUID CHROMATOFOCUSING [J].