GRIGNARD ADDITION TO 1-ACYL SALTS OF CHIRAL 4-ALKOXYPYRIDINES - A NEW ENANTIOSELECTIVE PREPARATION OF 2-ALKYL-2,3-DIHYDRO-4-PYRIDONES

被引：15

作者：

COMINS, DL

LAMUNYON, DH

机构：

[1] Department of Chemistry, North Carolina State University Raleigh

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 40期

关键词：

D O I：

10.1016/0040-4039(94)85309-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several 2-alkyl-2,3-dihydro-4-pyridones were prepared by asymmetric addition of Grignard reagents to the 1-acyl salts of chiral 4-alkoxypyridines.

引用

页码：7343 / 7346

页数：4

共 27 条

[1] CONVERSION OF N-ACYL-2,3-DIHYDRO-4-PYRIDONES TO 4-CHLORO-1,2-DIHYDROPYRIDINES USING THE VILSMEIER REAGENT - SYNTHESIS OF (-)-CONIINE AND (PLUS-OR-MINUS)-LUPININE
ALAWAR, RS
JOSEPH, SP
COMINS, DL
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (27) : 7732 - 7739
[2] CONVERSION OF N-ACYL-2,3-DIHYDRO-4-PYRIDONES TO 4-CHLORO-1,2-DIHYDROPYRIDINES USING THE VILSMEIER REAGENT
ALAWAR, RS
JOSEPH, SP
COMINS, DL
[J]. TETRAHEDRON LETTERS, 1992, 33 (50) : 7635 - 7638
[3] HIGHLY DIASTEREOSELECTIVE FORMATION OF SUBSTITUTED INDOLIZIDINES AND QUINOLIZIDINES BY RADICAL CYCLIZATION
BECKWITH, ALJ
JOSEPH, SP
MAYADUNNE, RTA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (16) : 4198 - 4199
[4] THE ISOXAZOLINE-5-SPIROCYCLOPROPANE ROUTE TO (+/-)-PUMILIOTOXIN-C
BRANDI, A
CORDERO, FM
GOTI, A
GUARNA, A
[J]. TETRAHEDRON LETTERS, 1992, 33 (44) : 6697 - 6700
[5] A HIGHLY STEREOCONTROLLED, 4-STEP SYNTHESIS OF (+/-)-LASUBINE-II
BROWN, JD
FOLEY, MA
COMINS, DL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (22) : 7445 - 7447
[6] A SHORT, ASYMMETRIC-SYNTHESIS OF (-)-PUMILIOTOXIN-C
COMINS, DL
DEHGHANI, A
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (24) : 1838 - 1839
[7] THE ADDITION OF ALKYLZINC IODIDES TO 1-(PHENOXYCARBONYL)-2,3-DIHYDROPYRIDINIUM SALTS - A SYNTHESIS OF 2-ALKYL-DELTA-3-PIPERIDINES
COMINS, DL
FOLEY, MA
[J]. TETRAHEDRON LETTERS, 1988, 29 (51) : 6711 - 6714
[8] CHIRAL DIHYDROPYRIDONES AS SYNTHETIC INTERMEDIATES - ASYMMETRIC-SYNTHESIS OF (+)-ELAEOKANINE-A AND (+)-ELAEOKANINE-C
COMINS, DL
HONG, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (17) : 6672 - 6673
[9] ASYMMETRIC-SYNTHESIS OF 2-ALKYL(ARYL)-2,3-DIHYDRO-4-PYRIDONES BY ADDITION OF GRIGNARD-REAGENTS TO CHIRAL 1-ACYL-4-METHOXYPYRIDINIUM SALTS
COMINS, DL
GOEHRING, RR
JOSEPH, SP
OCONNOR, S
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (09) : 2574 - 2576
[10] THE ADDITION OF METALLO-ENOLATES TO CHIRAL 1-ACYLPYRIDINIUM SALTS - AN ASYMMETRIC-SYNTHESIS OF (-)-SEDAMINE
COMINS, DL
HONG, H
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (19) : 5035 - 5036

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