THE EFFECT OF HISTAMINE ON THE OXIDATIVE BURST OF HL-60 CELLS BEFORE AND AFTER EXPOSURE TO REACTIVE OXYGEN SPECIES

被引:17
作者
CHING, TL [1 ]
KOELEMIJ, JG [1 ]
BAST, A [1 ]
机构
[1] VRIJE UNIV AMSTERDAM,LEIDEN AMSTERDAM CTR DRUG RES,DEPT PHARMACOCHEM,DIV MOLEC PHARMACOL,1081 HV AMSTERDAM,NETHERLANDS
关键词
HL-60; CELLS; DIBUTYRYL CAMP; HISTAMINE FORMYL-METHIONYL-LEUCYL-PHENYLALANINE; REACTIVE OXYGEN SPECIES;
D O I
10.1007/BF01782018
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During an inflammation neutrophils are stimulated to produce reactive oxygen species (ROS). These ROS induce the release of histamine from mast cells, which are also present at the inflammation site. In this study dibutyryl cAMP differentiated HL60 cells are used as a model for human neutrophils. The effect of histamine on formyl-methionyl-leucyl-phenylalanine (fmlp) stimulated cells is examined. Except for histamine also an accumulation of ROS takes place at the inflammation site and we investigated if ROS can influence the response of the stimulated HL60 cells. It is found that 10(-3) M histamine can inhibit the fmlp induced superoxide anion radical production. This occurs partly via an H-2 receptor because H-2 antagonists like famotidine, mifentidine and ranitidine could partially antagonize this effect of histamine. When HL60 cells are exposed to hydrogen peroxide or hypochlorous acid (20 min), an increased fmlp response is found while the inhibiting effect of histamine remains unchanged.
引用
收藏
页码:99 / 104
页数:6
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