PLASMA-PROTEIN ACCUMULATION IN INJURED ENDOTHELIAL-CELLS - IMMUNOFLUORESCENT LOCALIZATION OF IGG AND FIBRINOGEN IN THE RABBIT AORTIC ENDOTHELIUM

被引：51

作者：

HANSSON, GK

BONDJERS, G

NILSSON, LA

机构：

[1] UNIV GOTHENBURG,DEPT INTERNAL MED,S-40033 GOTHENBURG 33,SWEDEN

[2] UNIV GOTHENBURG,DEPT MED MICROBIOL,S-40033 GOTHENBURG 33,SWEDEN

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1979年 / 30卷 / 01期

关键词：

D O I：

10.1016/0014-4800(79)90078-9

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The relationship between endothelial cell injury in the rabbit aorta, and the distribution of the plasma proteins IgG, fibrinogen, and albumin were studied by immunofluorescence techniques. Normal rabbit aortae, as well as different types of experimentally induced atherosclerotic lesions, were studied. Injured endothelial cells were visualized by a dye exclusion test. Uninjured endothelial cells were found to be free from plasma proteins, except for a thin continuous lining of fibrinogen on the luminal side of the cells. In injured endothelial cells, there was an accumulation of both IgG and fibrinogen. Such cells were preferentially localized to branching-points, and the borders of atherosclerotic lesions. Albumin could neither be demonstrated in injured nor in uninjured cells. These observations indicate an uptake of IgG and fibrinogen by injured endothelial cells. The immunohistochemical method employed may be used to visualize injured endothelial cells. © 1979.

引用

页码：12 / 26

页数：15

共 27 条

[1] A NEW FLUORESCENT ANTIBODY METHOD - MIXED ANTIGLOBULIN IMMUNOFLUORESCENCE OR LABELLED ANTIGEN INDIRECT IMMUNOFLUORESCENCE STAINING [J].