REPRODUCTIVE FUNCTION IN RATS EXPOSED PRENATALLY TO PESTICIDES AND POLYCHLORINATED BIPHENYLS (PCB)

被引：41

作者：

GELLERT, RJ

WILSON, C

机构：

[1] Department of Obstetrics and Gynecology RH-20, University of Washington, Seattle

来源：

ENVIRONMENTAL RESEARCH | 1979年 / 18卷 / 02期

关键词：

D O I：

10.1016/0013-9351(79)90119-1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The pesticides methoxychlor, Kepone, dieldrin, aldrin, and the PCB's Aroclor 1221, 1242 and 1260 were fed to female rats during pregnancy in order to study reproductive function in the male and female offspring. Kepone alone produced significant reproductive aberrations. At 6 months of age the female offspring of Kepone-treated dams exhibited persistent vaginal estrus (PVE), anovulation, and tonic levels of serum estradiol. Other substances, such as methoxychlor and Aroclor 1221, previously shown to be estrogenic were not effective in altering reproductive function in the male or female offspring. The reproductive aberrations following Kepone exposure are thought to be due to alteration of hypothalamic differentiation during perinatal development. © 1979.

引用

页码：437 / 443

页数：7

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