LABORATORY INVESTIGATIONS IN PATIENTS WITH GENERALIZED PSORIASIS UNDER ORAL RETINOID TREATMENT - MULTICENTER STUDY OF COMPUTERIZED DATA

被引：62

作者：

ORFANOS, CE

MAHRLE, G

GOERZ, G

HAPPLE, R

HOFBAUER, M

LANDES, E

SCHIMPF, A

机构：

[1] UNIV COLOGNE,DEPT DERMATOL,D-5000 COLOGNE 41,FED REP GER

[2] UNIV DUSSELDORF,DEPT DERMATOL,D-4000 DUSSELDORF 1,FED REP GER

[3] UNIV HEIDELBERG,DEPT DERMATOL,D-6900 HEIDELBERG 1,FED REP GER

[4] UNIV HOMBURG,DEPT DERMATOL,D-6650 HOMBURG,FED REP GER

[5] UNIV MUNSTER,DEPT DERMATOL,D-4400 MUNSTER,FED REP GER

[6] UNIV GOTTINGEN,DEPT DERMATOL,D-3400 GOTTINGEN,FED REP GER

[7] UNIV DARMSTADT,DEPT DERMATOL,DARMSTADT,FED REP GER

来源：

DERMATOLOGICA | 1979年 / 159卷 / 01期

关键词：

Computer evaluation; Laboratory data; Liver function tests; Oral retinoid; Psoriasis; Therapy;

D O I：

10.1159/000250563

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Numerous laboratory parameters were examined in 235 patients with generalized psoriasis treated orally with retinoid and in 35 patients treated topically with anthralin as control. Computer evaluation of the obtained data revealed statistical trends to elevation of the total serum bilirubin level and increasing number of blood monocytes after long-term oral treatment. No other statistically significant changes of the laboratory data were found. Particularly, the liver function tests (transaminases, prothrombin and alkaline phosphatase) showed no significant alterations. Only in a few cases did the retinoid compound have an influence on the GPT and GOT levels. The reasons for this individual sensitivity to the drug remain unknown. No significant alterations were found in the control group treated topically with anthralin. © 1979 S. Karger AG, Basel.

引用

页码：62 / 70

页数：9

共 9 条

[1] TREATMENT OF PSORIASIS-VULGARIS WITH A NEW RETINOIC ACID-DERIVATIVE RO 10-9359 - UNCONTROLLED CLINICAL-TRIAL [J].