HIPPOCAMPAL 8-[H-3]HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN BINDING-SITE DENSITIES, SEROTONIN RECEPTOR (5-HT(1A)) MESSENGER-RIBONUCLEIC-ACID ABUNDANCE, AND SEROTONIN LEVELS PARALLEL THE ACTIVITY OF THE HYPOTHALAMOPITUITARY ADRENAL AXIS IN RAT

被引：77

作者：

BURNET, PWJ ^{[1
]}

MEFFORD, IN ^{[1
]}

SMITH, CC ^{[1
]}

GOLD, PW ^{[1
]}

STERNBERG, EM ^{[1
]}

机构：

[1] NIMH,CLIN EPIDEMIOL BRANCH,NEUROENDOCRINE IMMUNOL & BEHAV UNIT,BLDG 10,ROOM 3S-231,BETHESDA,MD 20892

来源：

JOURNAL OF NEUROCHEMISTRY | 1992年 / 59卷 / 03期

关键词：

HIPPOCAMPUS; SEROTONIN; SEROTONIN 5-HT(1A) RECEPTOR; HYPOTHALAMOPITUITARY; ADRENAL AXIS; FISCHER F344/N; LEWIS;

D O I：

10.1111/j.1471-4159.1992.tb08348.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously demonstrated that susceptibility of the Lewis rat to inflammatory disease, compared with the relatively resistant Fischer F344/N rat, is related to a hyporesponsive hypothalamopituitary-adrenal axis to inflammatory and other stress mediators. Because serotonin (5-HT) and the 5-HT1A receptor are important stimulators of this axis, we have investigated the levels of 8-[H-3]-hydroxy-2,3-(di-n-propylamino)tetralin binding sites, 5-HT1A mRNA, 5-HT, and 5-hydroxyindoleacetic acid in various brain regions of Lewis, outbred Harlan Sprague Dawley, and Fischer F344/N rats. Lewis rats expressed significantly fewer hippocampal and frontal cortical 8-[H-3]hydroxy-2,3-(di-ni-propylamino)tetralin binding sites and less 5-HT1A mRNA than Harlan Sprague Dawley and Fischer F344/N rats. Adrenalectomy increased the number of 8-[H-3]hydroxy-2,3-(di-n-propylamino)tetralin binding sites and 5-HT1A mRNA expression in the hippocampus of all three strains. Levels of hippocampal 5-HT in Fischer F344/N rats were significantly greater than levels detected in the same regions from Lewis and Harlan Sprague Dawley rats. Hypothalamic 5-HT and 5-hydroxyindoleacetic acid levels in Harlan Sprague Dawley rats were higher than the same area from the other two strains. Adrenalectomy increased the levels of 5-hydroxyindoleacetic acid in the hypothalamus of all three strains. We conclude that hippocampal 5-HT1A receptor densities and 5-HT levels in the rat parallel the activity and responsiveness of the hypothalamopituitary-adrenal axis.

引用

页码：1062 / 1070

页数：9

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