EFFECT OF HEMODIALYSIS ON LIPID-PEROXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH CHRONIC-RENAL-FAILURE

被引：154

作者：

TOBOREK, M

WASIK, T

DROZDZ, M

KLIN, M

MAGNERWROBEL, K

KOPIECZNAGRZEBIENIAK, E

机构：

[1] L WARYNSKI SILESIAN MED ACAD,DEPT BIOCHEM & CHEM,MEDYKOW,POLAND

[2] L WARYNSKI SILESIAN MED ACAD,DEPT PHARMACOL,MEDYKOW,POLAND

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1992年 / 41卷 / 11期

关键词：

D O I：

10.1016/0026-0495(92)90014-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency. © 1992.

引用

页码：1229 / 1232

页数：4

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