A PLASMODIUM-VINCKEI CYSTEINE PROTEINASE SHARES UNIQUE FEATURES WITH ITS PLASMODIUM-FALCIPARUM ANALOG

被引：11

作者：

ROSENTHAL, PJ

机构：

[1] Parasitology Laboratory, Department of Medicine, San Francisco General Hospital, San Francisco, CA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1173卷 / 01期

关键词：

MALARIA; CYSTEINE PROTEINASE; CHEMOTHERAPY; HEMOGLOBIN HYDROLYSIS; (P-VINCKEI); (PLASMODIUM-FALCIPARUM);

D O I：

10.1016/0167-4781(93)90250-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene encoding a cysteine proteinase of the murine malaria parasite Plasmodium vinckei has been identified and characterized. The gene encodes a papain-family proteinase that shares unique features with a previously described P. falciparum cysteine proteinase. We hypothesize that both enzymes mediate the hydrolysis of hemoglobin, and perhaps other Plasmodium-specific functions.

引用

页码：91 / 93

页数：3

共 12 条

[1] SEQUENCE HOMOLOGIES, HYDROPHOBIC PROFILES AND SECONDARY STRUCTURES OF CATHEPSIN-B, CATHEPSIN-H AND CATHEPSIN-L - COMPARISON WITH PAPAIN AND ACTINIDIN [J].