NATURAL-KILLER-CELL ACTIVITY AND PROGRESSION-FREE SURVIVAL IN OVARIAN-CANCER

被引：29

作者：

GARZETTI, GG ^{[1
]}

CIGNITTI, M ^{[1
]}

CIAVATTINI, A ^{[1
]}

FABRIS, N ^{[1
]}

ROMANINI, C ^{[1
]}

机构：

[1] INRCA ANCONA,CTR IMMUNOL,DEPT GERIATR MED,ANCONA,ITALY

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1993年 / 35卷 / 02期

关键词：

NATURAL KILLER CELL ACTIVITY; OVARIAN CANCER; PROGNOSIS; PROGRESSION-FREE SURVIVAL;

D O I：

10.1159/000292678

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A longitudinal evaluation of the natural killer (NK) cell activity of peripheral blood lymphocytes was performed in 17 patients with advanced ovarian cancer (treated surgically and with subsequent multiagent chemotherapy) for a median follow-up period of 32 months. At the time of primary treatment, the mean value of NK cell activity was significantly lower in patients who then had disease progression (p < 0.05) than in patients with progression-free survival. During the follow-up period, no significant modifications of the NK cell activity were observed; only at the time of clinical disease progression did the NK cell activity show a significant reduction. We conclude that the NK cell activity is a potentially important prognostic factor.

引用

页码：118 / 120

页数：3

共 9 条

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