SYNTHESIS OF WATER-SOLUBLE SUGAR-DERIVATIVES OF COMBRETASTATIN A-4

被引：20

作者：

BROWN, RT

FOX, BW

HADFIELD, JA

MCGOWN, AT

MAYALARP, SP

PETTIT, GR

WOODS, JA

机构：

[1] CHRISTIE HOSP NATL HLTH SERV TRUST,PATERSON INST CANC RES,CRC,DEPT EXPTL CHEMOTHERAPY,MANCHESTER M20 9BX,LANCS,ENGLAND

[2] ARIZONA STATE UNIV,CANC RES INST,TEMPE,AZ 85287

[3] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 05期

关键词：

D O I：

10.1039/p19950000577

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.

引用

页码：577 / 581

页数：5

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