CHRONIC ACTIVE AUTOIMMUNE HEPATITIS IN CHILDREN - STRONG ASSOCIATION WITH A PARTICULAR HLA-DR6 (DRB1-ASTERISK-1301) HAPLOTYPE

被引:85
作者
FAINBOIM, L
MARCOS, Y
PANDO, M
CAPUCCHIO, M
REYES, GB
GALOPPO, C
BADIA, I
REMONDINO, G
CIOCCA, M
RAMONET, M
FAINBOIM, H
SATZ, ML
机构
[1] UNIV BUENOS AIRES,FAC MED,DEPT MICROBIOL,BUENOS AIRES,DF,ARGENTINA
[2] HOSP NINOS DR RICARDO GUTIERREZ,SERV IMMUNOL,BUENOS AIRES,DF,ARGENTINA
[3] JUAN P GARRAHAN NATL HOSP PEDIAT,GASTROENTEROL SERV,BUENOS AIRES,DF,ARGENTINA
[4] A POSADAS HOSP NATL,GASTROENTEROL SECT,BUENOS AIRES,DF,ARGENTINA
[5] FRANCISCO J MUNIZ HOSP,HEPATOPATHOL INFECT UNIT,BUENOS AIRES,DF,ARGENTINA
关键词
D O I
10.1016/0198-8859(94)90008-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The association of HLA antigens and type I or ''lupoid'' CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3, chi(2) = 52.4, P-c = 0.00001). DNA typing showed that the HLA-DRB1*1301 allele was present in 32 out of 33 HLA-DR6 patients (66. 6% of all the C-CAH patients vs 10.5% in controls; RR = 16.2, chi(2) = 111.3, P-c 0.00001). Analysis of HLA-DQB1 alleles also showed a significant increase of DQB1*0603 (RR = 15.4, chi(2) = 106.5, P-c = 0.00001), an allele found in strong linkage disequilibrium with DRB1*1301. The association of CAH-C with this particular HLA-DRG haplotype has not been previously described for the adult onset CAH. This different HLA predisposition, together with the fact that extrahepatic autoimmune diseases occur frequently only in the adult form of the disease, suggest that the immunopathogenic mechanisms involved in the development of these diseases may be different.
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页码:146 / 150
页数:5
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