SURFACE EXPRESSION OF ONLY GAMMA-DELTA AND OR ALPHA-BETA-T-CELL RECEPTOR HETERODIMERS BY CELLS WITH 4 (ALPHA, BETA, GAMMA, DELTA) FUNCTIONAL RECEPTOR CHAINS

被引：50

作者：

SAITO, T

HOCHSTENBACH, F

MARUSICGALESIC, S

KRUISBEEK, AM

BRENNER, M

GERMAIN, RN

机构：

[1] NCI, BIOL RESPONSE MODIFIERS PROGRAM, BETHESDA, MD 20892 USA

[2] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DIV TUMOR VIROL, BOSTON, MA 02115 USA

[3] HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DEPT RHEUMATOL & IMMUNOL, BOSTON, MA 02115 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1988年 / 168卷 / 03期

关键词：

D O I：

10.1084/jem.168.3.1003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Surface expression of TCR dimers by cells synthesizing three or four distinct types of receptor chains was analyzed. Cells containing intact .gamma., .alpha., and .beta. chains had only .gamma..delta. dimers on the cell surface. In human PEER cells, addition of a functional .alpha. chain led to the loss of .gamma..delta. dimer expression and expression of only .alpha..beta. dimers. This result was not due to transcriptional down-regulation of the .gamma. or .delta. loci. In murine cells expressing all four chains, both .gamma..delta. and .alpha..beta. dimers could be demonstrated on a single cell. No other chain combinations (.alpha..gamma., .alpha..delta., .beta..gamma., or .beta..delta.) were detected. Thus, there is stringent control of assembly and/or transport of TCR heterodimers, such that functional receptors consist only of .alpha..beta. and .gamma..delta. pairs, and no additional repertoire diversity is generated by cross pairing.

引用

页码：1003 / 1020

页数：18

共 53 条

[1] DIVERSITY AND STRUCTURE OF GENES OF THE ALPHA-FAMILY OF MOUSE T-CELL ANTIGEN RECEPTOR [J].