INCREASED SEROTONIN 5-HT2 RECEPTOR-BINDING ON BLOOD-PLATELETS OF SUICIDAL MEN

被引:87
作者
BIEGON, A
GRINSPOON, A
BLUMENFELD, B
BLEICH, A
APTER, A
MESTER, R
机构
[1] ISRAEL DEF FORCES,DEPT MENTAL HLTH,JERUSALEM,ISRAEL
[2] NESS ZIONA MENTAL HLTH CTR,NESS ZIONA,ISRAEL
[3] TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL
关键词
5-HT2; receptors; Platelets; Serotonin; Suicide;
D O I
10.1007/BF02244400
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In search of a physiological marker of depression and suicidal behavior, serotonin receptors of the 5-HT2 type were studied on platelet membranes from 19 control and 22 suicidal subjects. All were young, drug - and medication free men (18-21-years-old). 5-HT2 receptor binding was assayed using tritiated ketanserine at two concentrations. Receptor binding in the suicidal subjects was significantly higher than controls at both concentrations, the mean difference being around 50%. A similar difference between patients with major depressive disorder and matched controls has been observed previously. These findings support the use of 5-HT2 receptors on platelets as a research and diagnostic tool in depression and suicide. © 1990 Springer-Verlag.
引用
收藏
页码:165 / 167
页数:3
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