IGE-CONTAINING IMMUNE-COMPLEXES IN SYNOVIAL-FLUID OF PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：10

作者：

DECLERCK, LS ^{[1
]}

STRUYF, NJ ^{[1
]}

BRIDTS, CH ^{[1
]}

BREEDVELD, FC ^{[1
]}

WESTEDT, ML ^{[1
]}

CATS, A ^{[1
]}

STEVENS, WJ ^{[1
]}

机构：

[1] UNIV INSTELLING ANTWERP,DEPT IMMUNOL & RHEUMATOL,UNIV SPL 1,B-2610 WILRIJK,BELGIUM

来源：

CLINICAL RHEUMATOLOGY | 1990年 / 9卷 / 02期

关键词：

IgE; Immune Complexes; Rheumatoid Arthritis; Synovial Fluid;

D O I：

10.1007/BF02031965

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence and composition of IgE-containing immune complexes in paired synovial fluid and serum of 42 patients with classical or definite rheumatoid arthritis were studied. IgE-containing immune complexes were found in 15/42 synovial fluids; 15 sera were also positive. The correlation between serum and synovial fluid complexed IgE levels was high (r=0.77). The mean ratio of synovial fluid/serum levels was 1.96, i.e. significantly higher than 0.33, the synovial fluid/serum ratio for alpha-2-macroglobulin (molecular weight 820 kD), which was taken as high molecular weight control protein (p<0.0001). Apart from IgE in immune complex form, monomeric IgE was also significantly higher in synovial fluid compared to serum (ratio = 2.94). Other constituents which could be found in the immune complexes, i.e. anti-IgE antibodies, rheumatoid factors and anticollagen antibodies, were also higher in synovial fluid than predicted. Our results suggest intra-articular production of IgE-containing complexes in the synovial fluid, in addition to possible exudation of the complexes from the serum. These findings provide further evidence for the role of IgE-containing immune complexes in rheumatoid synovitis. © 1990 Springer-Verlag.

引用

页码：176 / 181

页数：6

共 16 条

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