BIOMEDICAL APPLICATIONS OF CHIRAL LIQUID-CHROMATOGRAPHY

被引：6

作者：

CAMILLERI, P

机构：

[1] Smith Kline & French Research Ltd, Welwyn, Hertfordshire, AL6 9AR, The Frythe

来源：

BIOMEDICAL CHROMATOGRAPHY | 1991年 / 5卷 / 03期

关键词：

D O I：

10.1002/bmc.1130050307

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Many drugs are racemic and therefore much effort has to be devoted towards the stereoselective synthesis of the most effective or less harmful component of a racemic mixture. High performance liquid chromatography will play an important role in the clinical analysis of racemic drugs in anticipation of regulations that are currently being discussed and are expected to be enforced by the end of this decade. In this review a number of methods for chiral resolution are outlined. These include the formation of diastereoisomers and the use of chiral stationary phases or chiral mobile phase additives.

引用

页码：128 / 132

页数：5

共 26 条

[1]

ALBERT A, 1973, SELECTIVE TOXICITY

[2]

Annett R G, 1972, Anal Biochem, V47, P638, DOI 10.1016/0003-2697(72)90160-1

[3] OPTIMIZATION OF DETECTION SENSITIVITY FOR ENANTIOMERS OF METOPROLOL ON SILICA-BONDED ALPHA-1-ACID GLYCOPROTEIN [J].