SYNTHETIC CHAIN-SUBSTITUTED PHOSPHOLIPIDS - ION-TRANSPORT ACROSS THEIR BILAYER-MEMBRANES

被引：13

作者：

MENGER, FM

AIKENS, P

机构：

[1] Department of Chemistry, Emory University, Atlanta, Georgia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 07期

关键词：

D O I：

10.1002/anie.199208981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The passage of ions through phospholipid vesicles is facilitated by building alkyl substituents into the lipid chains. The effects of the size, position, and number of substituents on the ion flux can be studied by monitoring the decrease in fluorescence of a pH-sensitive dye within the vesicles on lowering the pH of the surrounding water. Substituents in the middle of the chains were most efficient in altering the flux. Such studies are of interest for the development of systems for controlling drug release.

引用

页码：898 / 900

页数：3

共 12 条

[1]

[Anonymous], 1988, LIPOSOMES DRUG CARRI

[2]

CAFISO DS, 1987, J BIOENERG BIOMEMBR, V19, P444

[3] PYRANINE (8-HYDROXY-1,3,6-PYRENETRISULFONATE) AS A PROBE OF INTERNAL AQUEOUS HYDROGEN-ION CONCENTRATION IN PHOSPHOLIPID-VESICLES [J].