COLORIMETRIC AND TITRIMETRIC ASSAY OF ISONIAZID

被引:47
作者
ELBRASHY, AM [1 ]
ELASHRY, SM [1 ]
机构
[1] MANSOURA UNIV,FAC PHARM,DEPT MED CHEM,MANSOURA,EGYPT
关键词
ISONIAZID; COLORIMETRY; TITRIMETRY; CHLORPROMAZINE HYDROCHLORIDE; 2-IODOXYBENZOATE; N-BROMOPHTHALIMIDE;
D O I
10.1016/0731-7085(92)80060-Z
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Two methods are proposed for the determination of isoniazid in pure form or in tablets. In the first method chlorpromazine hydrochloride, when treated with 2-iodoxybenzoic acid as an oxidant in 50% w/v o-phosphoric acid solution, is oxidized to chlorpromazine free radical which absorbs at 530 nm. The red free radical is readily reduced quantitatively by isoniazid to the colourless chloropromazine. The addition of isoniazid to a red solution of chlorpromazine free radical results in a decrease in absorbance in direct proportion to the quantity of isoniazid. This forms the basis for the quantitative determination of micro-quantities of isoniazid (3-18-mu-g ml-1). The second method involves the titrimetric determination of isoniazid using N-bromophthalimide as a titrant. The end-point is determined either directly using methyl red or amaranth as indicator, or by a back titration method in which a known excess of N-bromophthalimide solution is added to isoniazid solution and then the residual unreacted reagent is determined iodometrically. The results by the proposed procedures were in good agreement with those obtained by the official methods.
引用
收藏
页码:421 / 426
页数:6
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