EFFECT OF FLUVASTATIN SODIUM (XU62-320), A NEW INHIBITOR OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE, ON THE INDUCTION OF LOW-DENSITY-LIPOPROTEIN RECEPTOR IN HEPG2 CELLS

被引：34

作者：

HAYASHI, K

KUROKAWA, J

NOMURA, S

KUGA, Y

OHKURA, Y

KAJIYAMA, G

机构：

[1] First Department of Internal Medicine, Hiroshima University School of Medicine, Minami-ku, Hiroshima

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1167卷 / 02期

关键词：

FLUVASTATIN SODIUM (XU62-320); HMG-COA REDUCTASE INHIBITOR; LDL RECEPTOR; HEPG2; CELL;

D O I：

10.1016/0005-2760(93)90166-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of fluvastatin sodium (XU62-320), a new type of inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A, on the induction of LDL receptor in the human liver-derived cell line HepG2 was investigated. Fluvastatin sodium produced marked inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and induction of LDL receptor on HepG2 cells at a concentration of 0.1-1.0 muM. These results suggest that fluvastatin sodium has potential for use as a strong plasma cholesterol-lowering drug.

引用

页码：223 / 225

页数：3

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