DIFFERENCE IN HLA-LINKED GENETIC BACKGROUND BETWEEN MIXED CONNECTIVE-TISSUE DISEASE AND SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：48

作者：

DONG, RP

KIMURA, A

HASHIMOTO, H

AKIZUKI, M

NISHIMURA, Y

SASAZUKI, T

机构：

[1] KYUSHU UNIV,MED INST BIOREGULAT,DEPT GENET,3-1-1 MAIDASHI,HIGASHI KU,FUKUOKA 812,JAPAN

[2] JUNTENDO UNIV,DIV RHEUMATOL,TOKYO 113,JAPAN

[3] KEIO UNIV,DEPT INTERNAL MED,TOKYO 108,JAPAN

[4] KUMAMOTO UNIV,GRAD SCH MED SCI,DEPT NEUROSCI & IMMUNOL,DIV IMMUNOGENET,KUMAMOTO 860,JAPAN

来源：

TISSUE ANTIGENS | 1993年 / 41卷 / 01期

关键词：

DISEASE SUSCEPTIBILITY; MCTD; SLE; HLA CLASS-II GENES; DNA TYPING;

D O I：

10.1111/j.1399-0039.1993.tb01972.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have typed 64 Japanese patients with mixed connective tissue disease (MCTD) and 53 Japanese patients with systemic lupus erythematosus (SLE) for HLA-DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 genes by the HLA-DNA typing method using the PCR-SSOP technique. Frequencies of HLA-DRB1*0401, DRB1*0901, DRB4*0101, and DQA1*03 were increased and those of HLA-DRB1*0405 and DQB1*0401 were decreased in the patients with MCTD, while the frequencies of HLA-DRB1*1501, DRB5*0101, and DQB1*0602 were increased in the patients with SLE. The typing results suggest that susceptibility to MCTD is strongly associated with the HLA-DRB1* 0401-DRB4*0101-DQA1*03-DQB1*0301 haplotype, and that to SLE is associated with the HLA-DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602 haplotype. The observation that the MCTD-associated HLA alleles are distinct from the SLE-associated ones may support the clinical entity of MCTD different from SLE.

引用

页码：20 / 25

页数：6

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