VITAMIN-D SUPPLEMENTATION IN THE ELDERLY - REVIEW OF SAFETY AND EFFECTIVENESS OF DIFFERENT REGIMES

被引：27

作者：

BYRNE, PM

FREANEY, R

MCKENNA, MJ

机构：

[1] ST MICHAELS HOSP,DEPT MED,DUN LAOGHAIRE,DUBLIN,IRELAND

[2] UNIV COLL DUBLIN,DEPT PHYSIOL,DUBLIN,IRELAND

[3] ST VINCENTS HOSP,METAB LAB,DUBLIN 4,IRELAND

来源：

CALCIFIED TISSUE INTERNATIONAL | 1995年 / 56卷 / 06期

关键词：

VITAMIN-D SUPPLEMENTATION; ELDERLY;

D O I：

10.1007/BF00298580

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamin D deficiency is common in the elderly, especially in countries where effective sunlight or exposure to sunlight is limited. Two regimes for vitamin D supplementation-low-dose daily oral administration and intermittent high-dose administration-were examined with regard to safety and effectiveness. Eleven papers reporting studies in 449 elderly subjects were reviewed. On low-dose continuous supplementation mean concentration of 25 hydroxyvitamin D (25(OH)D) ranged from 57 to 105 nmol/L compared to 55 to 87 nmol/L following high-dose supplementation. These mean values fall within the physiological range for young adults. Hypercalcemia occurred in only 3 subjects and was associated with a predisposing cause in 2 of 3 subjects. We suggest that low dose continuous supplementation (10 to 20 mu g daily) is the regime of choice but high-dose intermittent supplementation (2.5 mg six monthly) may be suitable where compliance is poor.

引用

页码：518 / 520

页数：3

共 19 条

[1]

Lips P., Netelenbos J.C., Jongen M.J.M., Van Ginkel F.C., Althius A.L., Van Schaik C.L., Et al., Histomorphometric profile and vitamin D status in patients with femoral neck fractures, Metab Bone Dis Rel Res, 4, pp. 85-93, (1982)

[2]

Komar L., Nieves J., Cosman F., Rubin A., Shen V., Linsday R., Calcium homeostasis of an elderly population upon admission to a nursing home, J Am Geriatr Soc, 41, pp. 1057-1064, (1993)

[3]

Parfitt A.M., Osteomalacia and related disorders, Metabolic bone disease and clinically related disorders, pp. 329-396, (1990)

[4]

Webb A.R., Holick M.F., The role of sunlight in the cutaneous production of vitamin D, Ann Rev Nutr, 8, pp. 75-99, (1988)

[5]

Krall E.A., Sahyoun N., Tannenbaum S., Dallal G.E., Dawson-Hughes B., Effect of vitamin D on seasonal variations in parathyroid hormone secretion in postmenopausal women, N Engl J Med, 321, pp. 1777-1783, (1989)

[6]

McKenna M.J., Differences in vitamin D status between countries in young adults and the elderly, Am J Med, 93, pp. 69-77, (1992)

[7]

Chapuy M.C., Arlot M.E., Duboeuf F., Brun J., Crouzet B., Arnaud S., Delmas P.D., Meunir P.J., Vitamin D<sub>3</sub> and calcium to prevent hip fractures in elderly women, N Engl J Med, 327, pp. 1637-1641, (1992)

[8]

McKenna M.J., Freaney R., Meade A., Muldowney F.P., Prevention of hypovitaminosis D in the elderly, Calcif Tissue Int, 37, pp. 112-116, (1985)

[9]

Honkanen R., Alhava E., Parviainen M., Talasniemi S., Monkkonen R., The necessity and safety of calcium and vitamin D in the elderly, JAGS, 38, pp. 862-866, (1990)

[10]

Sorva A., Risteli L., Valimaki M., Tilvis R., Effects of vitamin D and calcium on markers of bone metabolism in geriatric patients with low serum 25-hydroxyvitamin D levels, Calcif Tissue Int, 49, pp. S88-S89, (1991)

← 1 2 →