ASYMMETRIC-SYNTHESIS OF ALPHA-AMINO-ACIDS VIA CHIRAL N-ALKYLIDENESULFINAMIDES

被引：61

作者：

HUA, DH

LAGNEAU, N

WANG, H

CHEN, JS

机构：

[1] Department of Chemistry, Kansas State University, Manhattan

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 02期

关键词：

D O I：

10.1016/0957-4166(95)00010-M

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(SR)-(-)-N-[1-(Triethoxymethyl)ethylidene]-p-toluenesulfinamide (2) was synthesized from the addition reaction of triethoxyacetonitrile with MeLi followed by (+)-(R)-d-menthyl p-toluenesulfinate (1R). Sulfinimine 2 underwent complete stereoselective reduction with 9-BBN and addition reaction with allylmagnesium bromide. Optically pure alpha-amino acids were synthesized from these adducts by simple hydrolysis.

引用

页码：349 / 352

页数：4

共 12 条

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