EFFECTS OF HYPOGLYCIN ON GLUCOSE-METABOLISM IN RAT - KINETIC STUDY INVIVO WITH [U-C-14,2-H-3]GLUCOSE

被引：21

作者：

OSMUNDSEN, H ^{[1
]}

BILLINGTON, D ^{[1
]}

TAYLOR, JR ^{[1
]}

SHERRATT, HSA ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE, SCH MED, DEPT PHARMACOL SCI, NEWCASTLE UPON TYNE NE1 7RU, TYNE & WEAR, ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1978年 / 170卷 / 02期

关键词：

D O I：

10.1042/bj1700337

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The kinetics of glucose metabolism were evaluated in rats deprived of food 15-21 h after the administration of hypoglycaemic doses of hypoglycin (100 mg/kg body wt.) by following changes in the specific radioactivities of 14C and 3H in blood glucose after an intravenous dose of [U-14C,2-3H]glucose. During this time, recycling of glucose through the Cori cycle was virtually abolished, the rate of irreversible disposal of glucose and its total body mass were both decreased by about 70% whereas there was little effect on the mean transit time for glucose. It was concluded that hypoglycaemia is due to inhibition of gluconeogenesis.

引用

页码：337 / 342

页数：6

共 40 条

[1]

[Anonymous], 1972, TRACER METHODS IN VI

[2] VERSATILE DIGITAL COMPUTER PROGRAM FOR NON-LINEAR REGRESSION ANALYSIS [J].