IS THE DOPAMINERGIC MESOCORTICOLIMBIC SYSTEM NECESSARY FOR INTRACRANIAL SELF-STIMULATION - BIOCHEMICAL AND BEHAVIORAL-STUDIES FROM A-10 CELL-BODIES AND TERMINALS

被引：70

作者：

SIMON, H ^{[1
]}

STINUS, L ^{[1
]}

TASSIN, JP ^{[1
]}

LAVIELLE, S ^{[1
]}

BLANC, G ^{[1
]}

THIERRY, AM ^{[1
]}

GLOWINSKI, J ^{[1
]}

LEMOAL, M ^{[1
]}

机构：

[1] COLL FRANCE,INSERM,U114,F-75005 PARIS,FRANCE

来源：

BEHAVIORAL AND NEURAL BIOLOGY | 1979年 / 27卷 / 02期

关键词：

D O I：

10.1016/S0163-1047(79)91745-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The role of mesocortical and mesolimbic A10-dopaminergic neurons was tested in a self-stimulation paradigm. In a first experiment, we showed a significant activation of the A10 neurons as a result of bilateral self-stimulation of A10 cell bodies in the ventral tegmental area. This activation as measured by the ratio between endogenous dihydroxyphenylacetic acid and dopamine, was greater in the medical prefrontal cortex than in the nucleus accumbens. In a second experiment, we showed that self-stimulation obtained from A10 terminal regions in the medial prefrontal cortex and in the nucleus accumbens was not reduced by near total destruction of A10 cell bodies. In contrast we observed an increase in self-stimulation from the nucleus accumbens. On the basis of these results it may be stated that the dopamine of A10 neurons is not critical in maintaining self-stimulation from medial prefrontal cortex and from nucleus accumbens. While a role for dopamine in self-stimulation cannot be excluded, there are most likely other noncatecholaminergic systems involved. © 1979 Academic Press, Inc.

引用

页码：125 / 145

页数：21

共 68 条

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