GENOME-RELATED DATASETS WITHIN THE ESCHERICHIA-COLI GENETIC STOCK CENTER DATABASE

被引:20
作者
BERLYN, MB [1 ]
LETOVSKY, S [1 ]
机构
[1] LETOVSKY ASSOCIATES, NEW HAVEN, CT 06515 USA
基金
美国国家科学基金会;
关键词
D O I
10.1093/nar/20.23.6143
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The contents of the E.coli Genetic Stock Center database and the availability in electronic form of the subset of information most relevant to sequence databases are described. The database uses the long-standing Stock Center records (developed and curated by Dr B.J.Bachmann) in describing genotypes of mutant derivatives of E.coli K-12 in terms of alleles, structural mutations, mating type, and plasmids as well as the derivation, names and originators of the strain, and references. The database includes descriptions of mutations, mutation properties, genes, gene properties, and gene products, with EC number identifiers for enzymes. Sequence information is not included, but entries refer to sequence database accession numbers for sequenced regions. A gene is described as a subtype of a more general category of chromosome interval called Site. Since sites are used to describe any chromosomal interval, mapping information is associated with sites. Alleles are described as mutations of those sites and they are not primary map objects, but inherit map position information from the corresponding site description. The database design is intended to preserve richness of detail where it is known and uncertainty of measurements or information as it occurs in order to represent the stock center records as accurately as possible.
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页码:6143 / 6151
页数:9
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