MULTIPOINT MAPPING OF THE CENTRAL CORE DISEASE LOCUS

被引：10

作者：

SCHWEMMLE, S

WOLFF, K

PALMUCCI, LM

GRIMM, T

LEHMANNHORN, F

HUBNER, C

HAUSER, E

ILES, DE

MACLENNAN, DH

MULLER, CR

机构：

[1] UNIV WURZBURG,BIOZENTRUM,INST HUMANGENET,W-8700 WURZBURG,GERMANY

[2] UNIV TURIN,IST CLIN MALATTIE SISTEMA NERVOSA,I-10124 TURIN,ITALY

[3] UNIV ULM,ANGEW PHYSIOL ABT,W-7900 ULM,GERMANY

[4] UNIV HAMBURG,KINDERKLIN EPPENDORF,W-2000 HAMBURG 20,GERMANY

[5] UNIV VIENNA,KINDERKLIN,A-1010 VIENNA,AUSTRIA

[6] UNIV HOSP NIJMEGEN,DEPT CELL BIOL & HISTOL,NIJMEGEN,NETHERLANDS

[7] UNIV TORONTO,BANTING & BEST DEPT MED RES,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

GENOMICS | 1993年 / 17卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1302

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A linkage analysis with 12 DNA markers from proximal 19q was performed in eight families with central core disease (CCO). Two-point analysis gave a peak lod score of Z = 4.95 at θ = 0.00 for the anonymous marker D19S190 and of Z = 2.53 at θ = 0.00 for the ryanodine receptor (RYR1) candidate gene. Multipoint linkage data place the CCO locus at 19q13.1, flanked proximally by D19S191/D19S28 and distally by D19S47. This map location includes the RYR1 gene. The results of the linkage study present no evidence for genetic heterogeneity of CCO. © 1995 Academic Press. All rights reserved.

引用

页码：205 / 207

页数：3

共 19 条

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