TRP-1 EXPRESSION CORRELATES WITH EUMELANOGENESIS IN HUMAN PIGMENT-CELLS IN CULTURE

被引：69

作者：

DELMARMOL, V

ITO, S

JACKSON, I

VACHTENHEIM, J

BERR, P

GHANEM, G

MORANDINI, R

WAKAMATSU, K

HUEZ, G

机构：

[1] UNIV LIBRE BRUXELLES,DEPT MOLEC BIOL,B-1050 BRUSSELS,BELGIUM

[2] FUJITA HLTH UNIV,SCH HYG,TOYOAKE,AICHI,JAPAN

[3] WESTERN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH,SCOTLAND

来源：

FEBS LETTERS | 1993年 / 327卷 / 03期

关键词：

BROWN; TYROSINASE; MELANOGENESIS; HUMAN;

D O I：

10.1016/0014-5793(93)81010-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.

引用

页码：307 / 310

页数：4

共 20 条

[1] THE HUMAN HOMOLOG OF THE MOUSE BROWN GENE MAPS TO THE SHORT ARM OF CHROMOSOME-9 AND EXTENDS THE KNOWN REGION OF HOMOLOGY WITH MOUSE CHROMOSOME-4
ABBOTT, C
JACKSON, IJ
CARRITT, B
POVEY, S
[J]. GENOMICS, 1991, 11 (02) : 471 - 473
[2] BENNETT DC, 1991, J CELL SCI, V98, P135
[3] NUCLEOTIDE-SEQUENCE OF THE CDNA-ENCODING HUMAN TYROSINASE-RELATED PROTEIN
COHEN, T
MULLER, RM
TOMITA, Y
SHIBAHARA, S
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (09) : 2807 - 2808
[4] MURINE AND HUMAN B-LOCUS PIGMENTATION GENES ENCODE A GLYCOPROTEIN (GP75) WITH CATALASE ACTIVITY
HALABAN, R
MOELLMANN, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4809 - 4813
[5] ENZYMATIC CONTROL OF PIGMENTATION IN MAMMALS
HEARING, VJ
TSUKAMOTO, K
[J]. FASEB JOURNAL, 1991, 5 (14) : 2902 - 2909
[6] MICROANALYSIS OF EUMELANIN AND PHEOMELANIN IN HAIR AND MELANOMAS BY CHEMICAL DEGRADATION AND LIQUID-CHROMATOGRAPHY
ITO, S
FUJITA, K
[J]. ANALYTICAL BIOCHEMISTRY, 1985, 144 (02) : 527 - 536
[7] A 2ND TYROSINASE-RELATED PROTEIN, TRP-2, MAPS TO AND IS MUTATED AT THE MOUSE SLATY LOCUS
JACKSON, IJ
CHAMBERS, DM
TSUKAMOTO, K
COPELAND, NG
GILBERT, DJ
JENKINS, NA
HEARING, V
[J]. EMBO JOURNAL, 1992, 11 (02) : 527 - 535
[8] JACKSON IJ, 1985, P NATL ACAD SCI USA, V85, P4392
[9] ASSAYS FOR MAMMALIAN TYROSINASE - A COMPARATIVE-STUDY
JARA, JR
SOLANO, F
LOZANO, JA
[J]. PIGMENT CELL RESEARCH, 1988, 1 (05): : 332 - 339
[10] JIMENEZ M, 1991, J BIOL CHEM, V266, P1147

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