EFFECTS OF NITRIC-OXIDE (NO) SYNTHESIS INHIBITION ON THE DEVELOPMENT OF SUPERSENSITIVITY TO STEREOTYPY AND LOCOMOTION STIMULATING EFFECTS OF METHAMPHETAMINE

被引：17

作者：

ABEKAWA, T

OHMORI, T

KOYAMA, T

机构：

[1] Department of Psychiatry, Hokkaido University School of Medicine, Kitaku, Sapporo, Kita 15

来源：

BRAIN RESEARCH | 1995年 / 679卷 / 02期

关键词：

METHAMPHETAMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; LNAME;

D O I：

10.1016/0006-8993(95)00207-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the effects of nitric oxide (NO) synthase inhibitor, N omega-nitro-L-arginine methyl ester (LNAME; 30 and 60 mg/kg, i.p.) on the development of supersensitivity to stereotypy as well as locomotion stimulating effects of methamphetamine (MA) (3.22 and 0.805 mg free base/kg, s.c., respectively). Rats treated with MA for 10 days showed enhancement in MA-induced stereotypy and locomotor activity. Rats pretreated with LNAME prior to MA also showed enhancement in the two types of behavior, also they showed significantly reduced stereotypy scores compared to those treated with MA alone. The results suggest that NO synthesis is not critically involved in the development of behavioral supersensitivity to stereotypy stimulating as well as locomotion stimulating effect of MA. However, NO synthesis may have a modulatory role in behavioral sensitization in stereotypy.

引用

页码：200 / 204

页数：5

共 25 条

[1]

Abekawa, Ohmori, Koyama, Effects of repeated administration of a high dose of methamphetamine on dopamine and glutamate release in rat striatum and nucleus accumbens, Brain Res., 643, pp. 276-281, (1994)

[2]

Abekawa, Ohmori, Koyama, Effects of NO synthase inhibition on behavioral changes induced by a single administration of methamphetamine, Brain Res., 666, pp. 147-150, (1994)

[3]

Bredt, Snyder, Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum, Proc. Natl. Acad. Sci. USA, 86, pp. 9030-9033, (1989)

[4]

Bredt, Hwang, Snyder, Localization of nitric oxide synthase indicating a neural role for nitric oxide, Nature, 347, pp. 768-770, (1990)

[5]

Dougherty, Ellinwood, Influence of gammabutyrolactone on behavior due to dopaminergic drugs, Physiol. Behav., 30, pp. 607-612, (1983)

[6]

Dwyer, Bredt, Snyder, Nitric oxide synthase: irreversible inhibition byl-NG-nitroarginine in brain in vitro and in vivo, Biochem. Biophys. Res. Commun., 176, pp. 1136-1141, (1991)

[7]

Garthwaite, Garthwaite, Palmer, Moncada, NMDA receptor activation nitric oxide synthesis from arginine in rat brain slices, Eur. J. Pharmacol., 172, pp. 413-416, (1989)

[8]

Garthwaite, Glutamate, nitric oxide and cell-cell signalling in the nervous system, Trends Neurosci., 14, pp. 60-67, (1991)

[9]

Gough, Holson, Slikker, Bower, Effects of nitric oxide synthetase inhibition and adenosine receptor antagonism on extracellular dopamine levels during methamphetamine exposure, Soc. Neurosci. Abstr., (1993)

[10]

Kalivas, Weber, Amphetamine injection into the ventral mesencephalon sensitize rats to peripheral amphetamine and cocaine, J. Pharmacol. Exp. Ther., 245, pp. 1095-1102, (1988)

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