THE SYNTHESIS OF D,L P-VINYLPHENYLGLYCINE BY AMIDOALKYLATION, AND ITS REACTIONS

被引：5

作者：

SHEFFERDEENOOR, S

BENISHAI, D

机构：

[1] Department of Chemistry, Technion - Israel Institute of Technology, Haifa

来源：

TETRAHEDRON | 1994年 / 50卷 / 23期

关键词：

D O I：

10.1016/S0040-4020(01)81353-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amidoalkylation of (2-chloroethyl)benzene or (2-bromoethyl)benzene with alpha-hydroxyhippuric acid and N-methoxycarbonyl alpha-hydroxyglycine, followed by dehydrohalogenation, affords N-protected p-vinylphenylglycines. Transformation of the vinyl group leads to N-methoxyycarbonyl-p-[1-(methoxycarbonylamino)ethyl]phenylglycine, N-methoxycarbonyl-p-(epoxyethyl) phenylglycine, N-methoxycarbonyl-p-formyl phenylglycine and N-methoxycarbonyl-p-carboxy phenylglycine. The deprotection of these compounds is described.

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页码：7009 / 7018

页数：10

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