DISTRIBUTION OF EQUID HERPESVIRUS-1 (EHV-1) IN RESPIRATORY-TRACT ASSOCIATED LYMPHOID-TISSUE - IMPLICATIONS FOR CELLULAR-IMMUNITY

被引：102

作者：

KYDD, JH

SMITH, KC

HANNANT, D

LIVESAY, GJ

MUMFORD, JA

机构：

[1] Department of Infectious Diseases, Animal Health Trust, Newmarket, CB8 7DW

来源：

EQUINE VETERINARY JOURNAL | 1994年 / 26卷 / 06期

基金：

英国惠康基金;

关键词：

HORSE; EHV-1; LYMPH NODES; VIRUS;

D O I：

10.1111/j.2042-3306.1994.tb04052.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Twelve adult ponies and 2 conventional foals were exposed intranasally to EHV-1, strain Ab4 (TCID50 10(-6.6) and samples of respiratory tract associated lymphoid tissues were recovered between 12 h and 13 days after infection. Infectious virus was detected in tissue homogenates using susceptible cell monolayers and expression of viral antigens was monitored using indirect immunoperoxidase histochemistry on paraffin sections. The results showed both infectious EHV-1 and viral antigens in respiratory tract associated lymph nodes 12 h after exposure. Infected leucocytes were identified morphologically as lymphocytes, monocytes, macrophages and plasma cells. The rapid intracellular localisation of EHV-1 in lymph nodes implies that cell mediated immunity is an important aspect of the equine response to this virus.

引用

页码：470 / 473

页数：4

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