CLINICOPATHOLOGICAL CORRELATES OF CD56 EXPRESSION IN MULTIPLE-MYELOMA - A UNIQUE ENTITY

被引:29
作者
MATHEW, P [1 ]
AHMANN, GJ [1 ]
WITZIG, TE [1 ]
ROCHE, PC [1 ]
KYLE, RA [1 ]
GREIPP, PR [1 ]
机构
[1] MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL,ROCHESTER,MN 55905
关键词
CD56; MULTIPLE MYELOMA; EXPRESSION;
D O I
10.1111/j.1365-2141.1995.tb05175.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Prior studies have suggested that loss of plasma cell CD56 expression in multiple myeloma defines a unique patient subset and that CD56 expression reliably discriminates between monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). We conducted a study of 68 untreated patients with MM from a single institution to define the clinicopathological correlates of CD56 expression. We find CD56 expression in 55% of MM. Lack of CD56 expression does not define a unique clinicopathological or prognostic entity in MM. Strong Cd56 expression can also be found in MGUS and does not help to distinguish from MM.
引用
收藏
页码:459 / 461
页数:3
相关论文
共 11 条
[1]   EXPRESSION OF ADHESION MOLECULES LFA-3 AND N-CAM ON NORMAL AND MALIGNANT HUMAN PLASMA-CELLS [J].
BARKER, HF ;
HAMILTON, MS ;
BALL, J ;
DREW, M ;
FRANKLIN, IM .
BRITISH JOURNAL OF HAEMATOLOGY, 1992, 81 (03) :331-335
[2]   NEURAL CELL-ADHESION MOLECULE - STRUCTURE, IMMUNOGLOBULIN-LIKE DOMAINS, CELL-SURFACE MODULATION, AND ALTERNATIVE RNA SPLICING [J].
CUNNINGHAM, BA ;
HEMPERLY, JJ ;
MURRAY, BA ;
PREDIGER, EA ;
BRACKENBURY, R ;
EDELMAN, GM .
SCIENCE, 1987, 236 (4803) :799-806
[3]  
DARCH J, 1991, CLIN EXPT IMMUNOLOGY, V83, P418
[4]   PROGNOSIS IN MYELOMA [J].
GREIPP, PR .
MAYO CLINIC PROCEEDINGS, 1994, 69 (09) :895-902
[5]  
GROGAN TM, 1993, BLOOD, V81, P490
[6]   IDENTITY OF LEU-19 (CD56) LEUKOCYTE DIFFERENTIATION ANTIGEN AND NEURAL CELL-ADHESION MOLECULE [J].
LANIER, LL ;
TESTI, R ;
BINDL, J ;
PHILLIPS, JH .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (06) :2233-2238
[7]   MULTIPARAMETER ANALYSES OF NORMAL AND MALIGNANT HUMAN PLASMA-CELLS - CD38++, CD56+, CD54+, CIG+ IS THE COMMON PHENOTYPE OF MYELOMA CELLS [J].
LEO, R ;
BOEKER, M ;
PEEST, D ;
HEIN, R ;
BARTL, R ;
GESSNER, JE ;
SELBACH, J ;
WACKER, G ;
DEICHER, H .
ANNALS OF HEMATOLOGY, 1992, 64 (03) :132-139
[8]   CELL-SURFACE MARKERS IN MULTIPLE-MYELOMA [J].
RUIZARGUELLES, GJ ;
SANMIGUEL, JF .
MAYO CLINIC PROCEEDINGS, 1994, 69 (07) :684-690
[9]   ANALYSIS OF MULTIDRUG-RESISTANCE (MDR-1) GLYCOPROTEIN AND CD56 EXPRESSION TO SEPARATE MONOCLONAL GAMMOPATHY FROM MULTIPLE-MYELOMA [J].
SONNEVELD, P ;
DURIE, BGM ;
LOKHORST, HM ;
FRUTIGER, Y ;
SCHOESTER, M ;
VELA, EE .
BRITISH JOURNAL OF HAEMATOLOGY, 1993, 83 (01) :63-67
[10]  
VANCAMP B, 1990, BLOOD, V76, P377