TRANSCRIPTIONAL REGULATION OF CELLULAR AND VIRAL PROMOTERS BY THE HEPATITIS-C VIRUS CORE PROTEIN

被引：245

作者：

RAY, RB ^{[1
]}

LAGGING, LM ^{[1
]}

MEYER, K ^{[1
]}

STEELE, R ^{[1
]}

RAY, R ^{[1
]}

机构：

[1] ST LOUIS UNIV,INST MOLEC VIROL,ST LOUIS,MO 63103

来源：

VIRUS RESEARCH | 1995年 / 37卷 / 03期

关键词：

HEPATITIS C VIRUS; CORE PROTEIN; TRANSCRIPTIONAL REGULATION; CELLULAR PROMOTER; VIRAL PROMOTER;

D O I：

10.1016/0168-1702(95)00034-N

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The genomic region encoding the hepatitis C virus (HCV) core protein was cloned into a mammalian expression vector to study its role on the transcriptional regulation of cellular proto-oncogene and viral promoters. Using a transient transfection assay in human hepatocellular carcinoma (HepG2) cells, we demonstrate that the HCV core protein activates the human c-myc, Rous sarcoma virus long terminal repeat (LTR), and simian virus 40 (SV40) early promoters; and suppresses the c-fos promoter and human immunodeficiency virus type 1 (HIV-1) LTR activity. The transcriptional regulation of cellular proto-oncogenes by the HCV core protein suggests possible involvement of the core protein in the deregulation of normal hepatocyte growth and hepatocarcinogenesis.

引用

页码：209 / 220

页数：12

共 32 条

[1] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS [J].